Investigation of neurological signs discount levitra plus uk erectile dysfunction drugs cost comparison, including cerebral imaging cheap 400mg levitra plus overnight delivery impotence trials france, in pregnancy are the same as Summary box 15. The incidence of maternal mortality from a cerebral Cerebral vein thromboses are more common in preg- haemorrhage was 0. Risk factors for cerebral haemorrhage include advanced maternal age, African American race, hyper- tensive disorders with poor blood pressure control, Acute abdominal complications coagulopathy and drug abuse. The period of greatest risk is during the postpartum interval, and this risk is height- Up to 2% of all pregnant women will require general ened by increasing maternal age. Blood pressure can surgery, with appendectomy and cholecystectomy often be most difficult to control postnatally. The estimated risk of fetal risk of vascular rupture during labour is not possible loss is 20% with a perforated appendix as opposed to 5% from the literature. Diagnosis of such complications can those with a previous cerebral haemorrhage must be be difficult and requires an experienced opinion. The individualized and reflect the patient’s wishes, parity and data on route of surgery for appendectomy and chole- recommendations from the neurosurgeon. There is a sugges- management decisions regarding embolization (and the tion of a higher rate of fetal loss with laparoscopic degree of radiation exposure) should be jointly made by approaches, though timing of surgery – with implica- obstetricians and neurosurgeons. Pregnancy should not tions for the level of inflammatory insult – is more alter the management of an acute stroke; pregnant important than the route of surgery . Caution is 204 Maternal Medicine required during the procedure and afterwards, given the need for full investigation of possible malignancy, the risks of preterm delivery and the risk that contrac- treatment in the same manner as in the non‐pregnant tions may be masked by perioperative analgesia. Quiescent disease at conception is always masked by the abdominal and breast changes of preg- a good prognostic sign, with up to 80% remaining in nancy. Relapse is often related to discontinuation of view of greater vascularity with pregnancy, more medications. Chemotherapy and radiotherapy can be consid- nancy and to deliver at a unit with supportive care for the ered in pregnancy, based on the increasing volume of neonate in the event of prematurity. There is a same way in pregnancy as in the non‐pregnant state; modest but generally reassuring level of data looking steroids and 5‐aminosalicylic acid compounds (e. Supplementation with haematinics and vita- most significant predictor of impairment of neonatal min D may be required. The inci- sus group lists ileorectal anastomosis or ileoanal pouch dence of pregnancy‐related breast cancer is approximately as a relative indication for caesarean section; neverthe- 1 in 1000, and is likely to increase with advancing mater- less the decision still has to be individualized to each nal age. Termination of pregnancy is most likely to be considered Malignant disease if breast cancer is diagnosed in the first trimester, but treatment strategies that allow continuation of the preg- the overall incidence of malignant disease in pregnancy nancy may be considered. Radiotherapy has there has been an increasing preparedness to investigate been used, but requires careful counselling dependent and treat malignant disease in much the same way as in on the gestational age, the dose required and the poten- the non‐pregnant state. Chemotherapeutic protocols can of safety of chemotherapy in different contexts beyond be used that do not pose a significant risk to the fetus, the first trimester . Not all chemotherapeutic agents but are generally avoided in the weeks preceding deliv- are safe, examples including selective oestrogen receptor ery to minimize the risk of coincident neutropenia or modulators, tamoxifen and angiogenesis inhibitors. Similar princi- and thromboprophylaxis will all need to be considered as ples will apply to other tumours. A pragmatic approach part of the treatment profile in view of the nausea associ- has to be taken following a diagnosis of cancer in preg- ated with chemotherapy and the increased risk of throm- nancy that allows for the individual’s wishes, the gesta- bosis in this group. Histological examination of the placenta were breast, brain, haematological, melanoma, lung and should be carried out if there is suspected metastatic gastrointestinal) was similar to that in the non‐pregnant disease or when maternal death from malignancy occurs. Older mothers were at greater risk of malignancy If placental metastatic disease is identified, neonatal and also of dying as a result of it. Autoimmune Rheumatic Diseases and Other Medical Disorders in Pregnancy 205 Table 15. Average dose absorbed Average dose absorbed by Procedure Typical effective dose (mSv)* by breast tissue (mGy) uterus/fetus (mGy) Chest X‐ray 0. The risk of childhood leukae- mia is trivial, with 10 mGy resulting in one additional Maligancy can occur in pregnancy and should be investi- case in 1700 exposed individuals. However, most of the imag- ing performed (non‐interventional radiological proce- Imaging in pregnancy dures) will not result in such high levels of irradiation to the fetus. Pregnancy must not preclude effective imaging where Of greater concern is the exposure of active maternal clinically indicated. Hence, the imaging of choice for a preg- ventilation–perfusion (V/Q) scans are considered. The International Extremely high doses of radiation – beyond the doses for Commission for Radiological Protection has issued some conventional non‐interventional imaging – are neces- guidance regarding such risks . Imaging should not be withheld due to an unfounded These levels could be achieved during fluoroscopically fear of ionizing radiation in pregnancy. Clin J Am Soc profile and mortality rates of scleroderma renal crisis in Nephrol 2010;5:2060–2068. Am J Reprod Immunol gynecologic challenges in women with Ehlers–Danlos 2005;53:182–188. Occlusive thromboaortopathy imbalance early in pregnancy predicts adverse (Takayasu’s disease) and pregnancy. Clinical course and outcomes in patients with lupus and antiphospholipid management of 33 pregnancies and deliveries. Paediatr Drugs syndrome and future risk of accelerated cardiovascular 2013;15:329–334. Biologics in pregnancy: for the and Ireland Confidential Enquiries into Maternal Deaths obstetrician. Effects of prenatal exposure to cancer drugs before pregnancy, and during pregnancy and treatment on neurocognitive development: a review. Therefore in a population very different to that of the 1950s when obesity in pregnancy is a significant health issue. Friedman first described the ‘normal’ progress of labour, Obstetricians, when meeting an obese woman in early now known as the Friedman curve . Friedman’s curve may not apply to the embolism, the difficulty of fetal assessment, using obese, or even overweight, woman. While the immediate risks may be evident to any clini- cian in practice, what may not be appreciated are the Contraception, fertility and conception subtle risks of obesity in pregnancy, how even mild obe- sity may affect progress in labour, the relative malnutrition In adolescence, several studies have shown that obese of vitamins and minerals, maternal malabsorption and teenagers may have a higher number of sexual partners, consequent malnutrition as a result of bariatric surgery, older partners and less use of contraception . This is a as well as the effects of maternal obesity on both fetal worrying pattern that does not continue into adulthood, programming and long‐term risk of cardiovascular but does lead to concerns regarding pregnancy risk in a disease and the increased risk of childhood obesity. Safety of secreting a variety of hormones and inflammatory mark- contraception should also be discussed at length, includ- ers, including cytokines, leptin and adiponectin. These ing the risk of thromboembolism with some forms of adipocytokines can have profound effects on pregnancy. It is well recognized that obesity is increasing in preva- lence in both the developed and developing world. In contrast, Given the possible complications of obesity in preg- adolescents showed increased weight gain, with obese nancy the ethics of providing subfertility treatment to adolescents having more weight gain than normal‐ obese women may be hotly debated, with some centres weight adolescents. This is also an opportunity overall there is no significant reduction in efficacy in for pre‐pregnancy consultation, which will be outlined in obese women.
The secretion rate depends on the intrinsic activity of the transporter discount 400 mg levitra plus erectile dysfunction treatment canada, proximal tubule blood flow buy cheap levitra plus erectile dysfunction treatment bay area, and the percent of free or unbound drug. Tubular secretion can be an extremely efficient process with drug clearance rates exceeding filtration clearance . Impaired renal function impacts tubular secretion because endogenous and exogenous organic acids and bases accumulate and compete for the transporters required for active secretion. It is difficult to predict whether secretion will be increased or diminished, which may ultimately lead to drug toxicity or reduced efficacy . As the volume of fluid in the tubule decreases with this massive reabsorption, there can be a dramatic increase in drug concentration in the tubule, which promotes passive diffusion from inside the tubule into the plasma. Manipulation of urine pH can be used to decrease drug reabsorption and, therefore, increase excretion. Studies examining the pharmacokinetics of drugs used in the critically ill patient population are limited; most are performed in healthy volunteers or in relatively stable patients with a specific disease state. Patients with chronic kidney disease take multiple medications, and thus have an inherently increased risk of drug interactions, particularly in the context of altered pharmacokinetics associated with worsening renal dysfunction and critical illness. The next section of this chapter addresses some of the known pharmacokinetic changes and drug interactions that may occur in critically ill patients with renal impairment. Gastrointestinal edema, nausea and vomiting as a result of uremia, and delayed gastric emptying all affect drug absorption in this patient population. In addition, patients may have comorbidities that contribute to changes in drug absorption, such as diabetic gastroparesis, diarrhea, and cardiovascular failure. Patients with chronic kidney disease and diabetic gastroparesis often are prescribed prokinetic agents (e. The use of these agents may decrease enteral absorption of medications owing to decreased gastric transit time, leading to decreased therapeutic effects or delayed onset of action . Patients requiring phosphate binding medications or antacids (aluminum or calcium salts) are at risk for having these medications chelate or bind to other medications and decrease their absorption. To minimize chelation, certain medications administered enterally, such as ciprofloxacin, need to be spaced around the dosing of antacid/phosphate binders by at least 2 hours . Changes in gastric pH from antacids or other acid-suppressing medications may impair the dissolution process of other enteral medications, leading to incomplete drug absorption. Bioavailability studies are often lacking for critically ill patients, because most are conducted in healthy adults. For a majority of medications, however, the bioavailability for patients with impaired renal function is unchanged or increased . To avoid issues relative to uncertain bioavailability among critically ill patients, the intravenous route of administration is often preferred. Distribution the distribution of drugs with high binding affinity for plasma proteins can be significantly altered among critically ill patients with renal failure. Highly protein-bound drugs exist in a state of equilibrium between unbound (free) and bound drug (not free). This means that if binding decreases, the amount of free drug available to exert a pharmacologic and toxic effect increases. Drug–drug interactions can occur when two highly plasma protein–bound drugs (>90% bound to plasma proteins) compete for the same plasma protein. If drugs such as warfarin, phenytoin, valproic acid, and salicylates (all highly bound to albumin) are administered together, displacement-mediated drug interactions may occur . Drug binding interactions also occur among patients with poor renal function because of changes in the configuration of albumin. For example, the pharmacodynamic effects of phenytoin and warfarin are increased in patients with renal failure because of changes of albumin structure [17,18]. Critically ill patients often have reduced albumin levels because of malnutrition or the metabolic stress of acute illness (or both), and this can lead to higher free fractions of drugs and potentially increase the risk of toxicity. If a patient taking warfarin rapidly develops hypoalbuminemia as a result of critical illness, the result is an increased availability of free drug, resulting in an elevated international normalized ratio and potential risk for bleeding. The volume of distribution for drugs administered to critically ill patients with renal failure can fluctuate considerably as fluid status changes. This can affect the clearance of drugs, and also protein binding, by altering the amount of free drug available to be metabolized or eliminated or both. Although it is very difficult, if not impossible, to predict these changes in drug distribution, it is important for the clinician to be aware of the risks and monitor for the signs of efficacy and toxicity so that the interactions are recognized and corrected. Metabolism the kidneys also actively metabolize medications, and impaired renal function can affect both renal and hepatic drug metabolism. Therefore, clinicians may adjust drug dosages to account for diminished renal metabolism as well as decreased renal elimination [19,20]. Drugs that are oxidized by the cytochrome P450 2D6 isoenzyme are more likely affected than those metabolized by other isoenzymes . The clinical significance of these effects in critically ill patients with renal disease remains to be determined, and the true relevance is difficult to define, because critically ill patients often have impaired metabolic function from nonrenal causes, including hepatic damage, diminished hepatic blood flow, and use of medications that act as enzyme inhibitors or inducers. Elimination the kidney is an important organ for drug and metabolite elimination; however, determining drug elimination for the critically ill patient population is challenging. Critically ill patients each have a unique combination of factors that can affect renal drug clearance. Dysfunction of other organ systems can significantly alter renal drug clearance through various mechanisms. For example, renal perfusion may be reduced by low cardiac output from a cardiomyopathy or acute myocardial infarction or by shunting of blood away from the kidney to the heart, brain, and muscle secondary to increased sympathetic nerve activity. Both of these mechanisms decrease drug delivery to the glomeruli, thus reducing the clearance of drugs that are eliminated primarily by glomerular filtration. Patients with mechanical ventilation may have reduced cardiac output (owing to increased mean intrathoracic pressure), volume of distribution changes, and acid–base imbalance, which can also affect renal drug disposition. It is, therefore, important to consider the dialysis system and drug characteristics that affect drug clearance, in addition to the degree, if any, of residual renal function. Failure to consider dialysis drug clearance may significantly reduce drug efficacy or result in toxicity. Detailed information regarding the many individual factors that must be considered to estimate dialysis drug clearance is discussed elsewhere [28,29]. Postdialysis replacement doses are usually necessary if clearance is particularly efficient, or residual renal function is significant. When drugs are given in multiple daily doses, at least one of the daily doses should be administered soon after the completion of dialysis. Drug dosing in peritoneal dialysis is not discussed here because it is not commonly used in critically ill patients. Drug level monitoring is most useful for medications with established correlation between serum levels and drug efficacy or toxicity. Peak levels are usually drawn 1 to 2 hours after oral drug administration and approximately 30 to 60 minutes after parenteral administration to allow an appropriate period of time for tissue distribution (α phase).
The cohort can also be selected by a specific causes but which was aggravated by the physiological event such as year of birth (a birth cohort) purchase 400mg levitra plus erectile dysfunction doctors in orange county. The cohort design buy levitra plus in india erectile dysfunction aids, which can be ties during, but unrelated to, pregnancy or the either retrospective or prospective, allows the study of puerperium. It is costly and not to 1 year after abortion, miscarriage or delivery that is appropriate for rare diseases with a long latent period for the result of direct or indirect maternal causes. In a case–control study, partici- pants are selected on the basis of the outcome of interest. This can be further divided into: are selected without the outcome of interest to allow com- – Intrapartum stillbirth: a baby known to be alive at parisons to be made between exposures of interest. This can be For example, in the determinants of factors associated further divided into (i) early (0–6 completed days) with endometrial cancer in postmenopausal women and (ii) late (7–27 completed days). Data are ● Perinatal death: death of a fetus or a newborn in the then collected in both groups and factor(s) that are differ- perinatal period, which commences at 24 completed ent between the groups may demonstrate an association weeks’ gestation and ends before seven completed with the outcome of interest. Matching in case–control days after birth (total of stillbirths and early neonatal studies precludes the factor in which the groups are death). In the example cited, the effect of age on endometrial cancer cannot be determined. In common with all obser- vational studies, case–control studies do not prove causa- Cohort studies tion but instead demonstrate association. The strength of Cohort studies are a form of longitudinal observational association, coupled with biological plausibility, are some study used to analyse risk factors by studying groups of of the criteria used to suggest association as reported by people who do not have the disease either retrospectively the Bradford Hill Criteria (Table 33. The more specific an association between a factor and an effect, the bigger the probability of a causal relationship 4 Temporality the effect has to occur after the cause (and if there is an expected delay between the cause and expected effect, then the effect must occur after that delay) 5 Biological gradient Greater exposure should generally lead to greater incidence of the effect. In other cases, an inverse proportion is observed: greater exposure leads to lower incidence 6 Plausibility A plausible mechanism between cause and effect is helpful 7 Coherence Coherence between epidemiological and laboratory findings increases the likelihood of an effect 8 Experiment Occasionally it is possible to appeal to experimental evidence 9 Analogy the effect of similar factors may be considered Inherent within the design of case–control studies, the numbers and to select cohorts of disease and non‐dis- selection of cases and controls by the investigator pre- ease, and they are less time‐consuming since the main cludes any estimation of disease incidence. In contrast, prospective studies follow populations selected because they do not have the disease. In population risk studies, a mine true population risk (incidence of the disease in a large number of negative controls will be collected population) a larger cross‐sectional study or cohort depending on the disease incidence. A variation of this method is the nested of these studies are significantly higher, they provide an case–control study, where cases with a disease in a opportunity to specifically tailor data collection. A well‐designed study does have the the same cohort who have not yet developed the disease. Confounding is defined the nested case–control design is easier and less expen- as the alternative explanation to the association found sive than a full cohort approach. A confounder must are also particularly useful for rare diseases and diseases be associated with both the exposure and the outcome with long latency periods. If well designed, this approach and not be on the causal pathway between the expo- will also allow examination of multiple exposures of sure and the outcome. The temporal sequence of exposure and disease the association between coffee drinking and cancer is can sometimes be difficult to study in a case–control smoking. It is recognized that coffee drinkers are more study and certainly the size of the study will need to be likely to smoke and smoking is certainly associated with sufficiently large to study rare exposures, which often cancer. Identifying potential confounders allows inves- limits this design in some settings. At the studied after all the events and outcomes have already design stage this includes restricting the study popula- occurred. The data are collected from a given popula- tion, matching in case–control studies and randomiza- tion. However, this is reliant on the data collected on conducted by starting with two groups that are selected potential confounders. Unfortunately, bias cannot be corrected Meta‐analysis through statistical analysis and can only be minimized by Independent trials although well powered and designed at appropriate study design. Often trials are also repeated with con- Randomized controlled trials flicting results. This approach increases the power to potential for bias by random selection of participants to detect smaller differences that were not identified in indi- one intervention arm or to another intervention, non‐ vidual studies. The weighted average of the combined patients, health volunteers or communities (randomized effect size is estimated. This minimizes the possibility that con- the individual studies and the effect size observed. Down the left‐hand In some circumstances an open label trial is carried out, side are the trials included. The trial quoted above is the where it is not possible to blind either the clinician or the last of the four trials listed (first author Boulvain). On the patient but randomization is performed without bias at right‐hand side is a plot of the risk ratio for each of these time of therapy. Review: Induction of labour at or near term for suspected fetal macrosomia Comparison: I Induction versus expectant management Outcome: 3 Shoulder dystocia Study or subgroup Induction Expectant Risk Ratio Weight Risk Ratio n/N n/N M-H, Fixed, 95% Cl M-H, Fixed, 95% Cl Boulvain 2015 (I) 5/407 32/411 78. The time period is usually fixed at a year scale so that the confidence intervals are symmetrical but the population denominator is more of a problem. In about the means to prevent apparent exaggeration in gynaecology, depending on the disease being studied, the ratios greater than 1 when compared with those less than at‐risk female population may be different. The area of each square is proportional to the study’s is typically, but not absolutely, seen during the reproduc- weight. The overall meta‐analysed measure of effect is tive years; it has been estimated that it affects approxi- represented as the diamond on the bottom and the lat- mately 10% of all women at some point, but this is eral points indicate the confidence intervals. A vertical lifetime risk not incidence, which is risk of new cases line is plotted at unity and if the confidence intervals for within a risk group over a fixed period of time. This nificance (Gonen 1997, Tey 1995) but the most recent indicates the burden of the disease on society and is published in 2015 (Boulvain) provided an overall signifi- dependent on both the number of new cases and the cant result. The length of time the disease is present (prevalence=inci- overall pooled results also suggest a reduction in the risk dence×duration). This equation demonstrates the rela- of shoulder dystocia associated with induction of labour tionship between prevalence and incidence: when the at 37–40 weeks. Incidence is more useful in understanding disease aetiology as it reflects disease occurrence and also the response to Statistics interventions. In the classical example of the cases of puerperal fever described by Semmelweis , the higher the primary principle in statistics that is often not well incidence in one group suggested an aetiological factor described nor understood is that analysis performed on related to that group alone and the fall in incidence that a study population represents only a sample of the popu- followed the hand‐washing initiative demonstrated a lation. Therefore, incidence will vary comparison between study groups reflect the population with changes in aetiological factors and prevention. The Prevalence is dependent on the duration of disease and robustness of the sampling process will influence the the availability of cure. The longer the duration of dis- strength of statistical inference which can be applied ease, the higher the prevalence. The prevalence is also from the findings in the study population to the underly- dependent on the study population.
Getting some idea from frequency of pad change or oestrogen cream can be applied for about 2 weeks quality 400mg levitra plus erectile dysfunction stress. If a history of pro- is complete resolution of the labial adhesions in 90% of longed bleeding during surgical or dental procedures is cases cheap 400 mg levitra plus amex discount erectile dysfunction pills. In the case of failure of oestrogen treatment, topi- obtained, screening for a coagulopathy is appropriate. Gynaecological Disorders of Childhood and Adolescence 555 the clinician is faced with attempting to assess whether 12 weeks. Amenorrhoea rates of 60% at 1 year and 70% the child truly has menstrual loss that is medically seri- at 2 years can be achieved. The newer alternative is the ous or menstrual loss that is irritating and distressing levonorgestrel intrauterine system which has similar without being medically harmful. It requires a skilled physician to fit lish which of these is the case is by measuring the hae- and in some cases this may require sedation. Oral progestogens are sel- mother and child of the normal physiology of menstrual dom used for long‐term use and have significantly higher establishment, that the manifestation of the menstrual side‐effect rates. Progesterone‐only pills and etonorg- loss is normal and that it may take some time for the estrel implants are not used, as menstrual suppression is cycle to be established. However, it is imperative that the child is fol- pill is also used and the 30‐µg pills are best. Continuous lowed up at 6‐monthly intervals until the pattern of men- use can achieve amenorrhoea rates of 30–50%, although struation is established, as reassurance is the most breakthrough bleeding is a common problem. Again, an explanation is required so that the ● Menstrual disorders in adolescents are usually a reflec- mother and daughter understand the cause of the prob- tion of normal physiology. It would be unusual Primary dysmenorrhoea for either of these therapies to be unsuccessful in con- Primary dysmenorrhoea is defined as pain which begins trolling the menstrual loss. The manage- they should be stopped on an annual basis so that assess- ment of dysmenorrhoea in the teenager is no different ment may be made about whether or not the normal pat- from that in the adult (see Chapter 34). The use of both tern of menstruation has been established by maturation non‐steroidal anti‐inflammatory drugs and the oral con- of the hypothalamic–pituitary–ovarian axis. Thereafter, traceptive pill is pertinent in teenagers, but again failure the child requires no further medication. Again, follow‐ of these medications to control dysmenorrhoea should up is essential if reassurance is to be given appropriately. This again requires an explanation but more urgent attention from a medical point of view. This is a difficult problem in adolescence as the psycho- Progestogens are very much less likely to be effective in logical changes that are occurring during this time in a this group and the oral contraceptive pill is by far the woman’s life are often complex and stressful. It may be given continuously for a established that premenstrual syndrome is a stress‐ short period of time so that the anaemia can be corrected related disorder. Therefore in teenage girls undergoing using oral iron and then the pill may be used in the nor- puberty the stresses and emotional turbulence associ- mal way so that menstrual loss occurs monthly, if desired. These are very difficult to manage and are reported to be uncontrolled by these management strat- usually not medically treated but addressed through the egies should have an ultrasound scan performed to help of psychologists, if reassurance from the gynaecolo- exclude uterine pathology. Menstrual suppression Some girls will require menstrual suppression as a Hirsutism means of controlling their blood loss whilst hypotha- lamic maturity is attained. The most widely used is Hair follicles cover the entire body and different types of depot medroxyprogesterone acetate administered every hair are found in different sites. Androgens affect some 556 Childhood and Adolescence areas of the human body and increase hair growth rate Table 39. Androgens are Androgenic causes also involved in sebum production and may cause this to be excessive. In some women excessive hair growth may Congenital adrenal hyperplasia occur on the arms, legs, abdomen, breasts and back such Classic that it constitutes the problem of hirsutism. This may Late onset also be associated with acne, which may occur not only Androgen‐secreting tumours on the face but also on the chest and back. Androgenic causes include ity is very effective at lowering circulating androgens. If congenital adrenal hyperplasia and its late‐onset variant this is insufficient to gain control of hair growth, then and also androgen‐secreting tumours. The commonest the use of cyproterone acetate or spironolactone may be group constitutes women with polycystic ovarian syn- considered. These include hair removal by shav- considering a child with hirsutism but a large percent- ing, waxing or electrolysis of those areas which are par- age of patients have idiopathic hirsutism. It is important ticularly cosmetically sensitive and also the use of to remember that some girls will have a constitutional bleaches to change hair colour, thereby gaining cosmetic basis for their hirsutism and familial body hair patterns benefit. Treatment for hirsutism is the same as in the adult and is covered Summary box 39. In adolescence the mainstay in the treat- ment of androgen excess has been the oral contracep- ● Hirsutism in adolescents is often idiopathic or cultural. Recognizing and addressing this issue allows doctors to Spontaneous miscarriage is defined as the spontaneous improve patient care. These units also improve clinical tation, fetal demise is classified as a stillbirth. The triennial report (2005–2007) trimester miscarriages are less common, accounting reported one maternal death from spontaneous miscar for 1–4% of all miscarriages . While some second‐ riage, although there were 18 direct deaths from mater trimester miscarriages can be explained as first‐trimester nal sepsis including deaths in early pregnancy . The importance of accurately tant that while their anxiety is recognized, we proceed defining the different types of miscarriage is that it pro along safe and accepted diagnostic pathways to avoid vides the bedrock upon which comparative research can misdiagnosis. It is also important to recognize that be built, to better understand the relative benefits and pregnancy is a dynamic process and that a diagnosis of outcomes of treatment options (Table 40. Care must a 90% chance that the pregnancy will continue beyond be taken when relying solely on a clinical diagnosis the first trimester . For example, the rate of miscarriage varies depending on the gesta in cases where the clinical picture suggests complete tion of pregnancy and maternal age. Up to miscarriage, there will be ultrasound evidence of retained 50% of early pregnancies will fail within 4 weeks from products in 45% of patients . By 6 weeks’ gestation, the rate is one in five pregnancies and by the second trimester that has fallen Aetiology to 1 in 40 . Simple scoring systems and models exist that can help advise women on the likely viability of Although the causes of miscarriage in the first and sec their pregnancy using both clinical and ultrasound ond trimester appear different, there is inevitably some information . It is likely that abnormal implantation has a role 40 to play in some cases and this is an area of current 20 research. It is thought that up to 95% of chromosomally abnormal embryos result in miscarriage . By definition the measurements of the embryo or gestation sac do not meet the criteria for the diagnosis of a missed miscarriage.